@article{3236af5aafa548f0bee17eb9b8f5baf9,
title = "Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice",
abstract = "In mice, prior destruction of striatal 5-hydroxytryptamine (5-HT) neurons by intrastiatal or intraventricular injections of 5,7-dihydroxytryptamine did not abolish or attenuate DA depletions produced in striatum by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). This suggests that although they contain monoamine oxidase type B, the oxidative conversion of MPTP to 1-methyl-4-phenyl-pyridinium ion (MPP+) does not take place in 5-HT neurons. Likewise, decortication and kainic acid lesions did not prevent or enhance striatal MPTP-induced DA decrements suggesting that corticostriatal projections and striatal neurons are not involved in the mechanisms of MPTP neurotoxicity.",
keywords = "1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Decortication, Dopamine, Kainic acid lesion, MPTP, Mouse, Serotonergic neuron, Striatum",
author = "Eldad Melamed and Eli Pikarski and Anat Goldberg and Jutta Rosenthal and Anat Uzzan and Nissim Conforti",
note = "Funding Information: Supportedi,n part, by the Lena P. HarveyE ndow-ment Fund for NeurologicaRl esearchb, y the Jacob and Hilda BlausteinF oundationa ndby a grant from the Jewish CommunityF ederationo f San-Francisco, The PenninsulaM, arin and SonomaC ounties.",
year = "1986",
month = dec,
day = "3",
doi = "10.1016/0006-8993(86)90615-3",
language = "אנגלית",
volume = "399",
pages = "178--180",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}