Effect of rewarming in oxygenation and respiratory condition after neonatal exposure to moderate therapeutic hypothermia

Background: To assess changes in clinical condition and oxygenation in neonates after rewarming following moderate therapeutic hypothermia (MTH) for neonatal encephalopathy. Methods: Retrospective study of 28 neonates receiving MTH in a tertiary neonatal intensive care unit in Israel. We compared pre-and 24 h post-rewarming arterial oxygen saturation (SaO₂) as measured by the blood gases analyzer, pulse-oximetry saturation (SpO₂), and cardio-respiratory condition. Results: The SpO₂ declined from 96.9% (±2.9) before rewarming to 95.2% (±2.6) after rewarming (p < 0.001). Twelve neonates (42.9%) had clinical respiratory impairment (needing higher respiratory support or had new onset desaturations). In 16 neonates (57.1%) with no change in respiratory support after rewarming, SpO₂ decreased from 98.3 ± 1.9% to 95.6 ± 3.0% (p < 0.001) and SaO₂ decreased from 97.1 ± 1.7% to 96.0 ± 2.3% (p = 0.002). The mean SpO₂ decrease was greater than mean SaO₂ decrease (2.63 ± 1.8 and 1.1 ± 1.3 respectively, p = 0.021). Conclusion: Neonates who underwent MTH showed reduction in oxygenation after rewarming either by decreasing SpO₂ or increasing FiO₂ requirements. The SpO₂ decline was larger than the SaO₂ decline. We suggest careful monitoring of neonates after rewarming.