Effect of recombinant human growth hormone on random pattern flaps in rats

Avshalom Shalom, Liora Hollander, Melvyn Westreich

Research output: Contribution to journalArticlepeer-review

Abstract

Recombinant human growth hormone, a very potent anabolic hormone, plays a significant role in growth regulation, bone metabolism, and wound healing. This study evaluates its effect on random flap survival. Rats were randomly divided into 2 groups. A dorsal random flap, cephalically based, was used. One group received 5 mg/kg subcutaneous injection of recombinant human growth hormone 1 hour before surgery and a repeat dosage every 24 hours for 1 week. The others served as controls. At the end of 1 week, average weight and flap survival was evaluated. There was no difference in flap survival between the groups. Treated rats had gained significantly more weight. Recombinant human growth hormone had no beneficial effect on flap survival. The lack of a deleterious effect of the hormone on random flap survival and its significant effect on rat weight and well being supports its safe use during flap surgery.

Original languageEnglish
Pages (from-to)556-557
Number of pages2
JournalAnnals of Plastic Surgery
Volume63
Issue number5
DOIs
StatePublished - Nov 2009

Keywords

  • Flap survival
  • Growth hormone
  • Random flap
  • Rat
  • Surgery

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