Effect of prostaglandin A2 on RNA synthesis in embryonic mouse erythroid cells

M. Djaldetti, H. Bessler, J. Levi

Research output: Contribution to journalArticlepeer-review

Abstract

Prostoglandin A2 (PGA2) is shown to stimulate RNA synthesis in 12-day embryonic mouse liver cells, thus expressing an erythropoietin-like effect. This effect was found to be dose-dependent. There was no significant difference between the results observed with patients' plasma before and after dialysis and with or without addition of PGA2. Although the baseline activity of RNA synthesis in the presence of uremic plasma is less than that with normal plasma, the almost equal potentiation of RNA synthesis in erythroid cells incubated with both normal and uremic plasma obtained with PGA2 favors a direct, and not an erythropoietin-mediated, effect of this substance.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalNephron
Volume21
Issue number6
StatePublished - 1978
Externally publishedYes

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