Effect of pressure on echocardiographic videodensity from sonicated albumin: An in vitro model

S. Gottlieb, A. Ernst, R. S. Meltzer

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of different pressures (0, 10, 30, 60, 80, 100, 120, or 180 mm Hg) on the ultrasound contrast effect obtained from sonicated albumin was evaluated by videodensity decay curves in an in vitro model immersed in a water tank. Decay rates and half-times were calculated from the videodensity decay curves at each pressure. A significant (P < 0.0001) relation was found between contrast disappearance and pressure: the higher the pressure the more rapid the contrast disappearance. Release of pressure did not result in contrast reappearance. Contrast decrease with pressure may result from microbubble destruction or alteration in acoustic properties by pressure. These findings may help explain the limited success of sonicated albumin for systemic ultrasonographic arteriography and myocardial perfusion imaging after intravenous injection. An ideal contrast agent for contrast echo studies should be stable at physiologic pressures.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume14
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Contrast echo
  • Echocardiography
  • Sonicated albumin
  • Videodensity

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