Effect of preanaesthetic medication on anaesthesia with ici 35 868

L. P. Briggs, M. Bahar, H. T.B. Beers, R. S.J. Clarke, J. W. Dundee, P. J. Wright, D. M. Mcauley, M. P. O'neill

Research output: Contribution to journalArticlepeer-review


The effect of three commonly used premcdicants and a control on anaesthesia with ICI 35 868 is described Two randomized studies were performed-one a group study of induction characteristics at 2mgkg-1 and the other a detailed study in patients undergoing minor gynaecological surgery with an induction dose of 1.5mgkg-1 and maintenance with incremental doses plus 66% nitrous oxide in oxygen Premedication had little effect on the already good induction characteristics. Only heavy opiate premedication produced reliable induction at 1 5 mg kg-1, but with an increase in side-effects Diazepam appears to be the premedicant of choice, although the overall frequency of pain on injection has not been affected by premedication.

Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number3
StatePublished - Mar 1982
Externally publishedYes


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