Effect of prandial treatment timing adjustment, based on continuous glucose monitoring, in patients with type 2 diabetes uncontrolled with once-daily basal insulin: A randomized, phase IV study

Jacob Ilany*, Hamad Bhandari, Dan Nabriski, Yoel Toledano, Noa Konvalina, Ohad Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Aims: To evaluate the glycaemic control achieved by prandial once-daily insulin glulisine injection timing adjustment, based on a continuous glucose monitoring sensor, in comparison to once-daily insulin glulisine injection before breakfast in patients with type 2 diabetes who are uncontrolled with once-daily basal insulin glargine. Materials and Methods: This was a 24-week open-label, randomized, controlled, multicentre trial. At the end of an 8-week period of basal insulin optimization, patients with HbA1c ≥ 7.5% and FPG < 130 mg/dL were randomized (1:1) to either arm A (no sensor) or arm B (sensor) to receive 16-week intensified prandial glulisine treatment. Patients in arm A received pre-breakfast glulisine, and patients in arm B received glulisine before the meal with the highest glucose elevation based on sensor data. The primary outcome was mean HbA1c at week 24 and secondary outcomes included rates of hypoglycaemic events and insulin dosage. Results: A total of 121 patients were randomized to arm A (n = 61) or arm B (n = 60). There was no difference in mean HbA1c at week 24 between arms A and B (8.5% ± 1.2% vs 8.4% ± 1.0%; P =.66). The prandial insulin glulisine dosage for arm A and arm B was 9.3 and 10.1 units, respectively (P =.39). The frequency of hypoglycaemic events did not differ between study arms (36.1% vs 51.7%; P =.08). Conclusion: Using a CGM sensor to identify the meal with the highest glucose excursion and adjusting the timing of prandial insulin treatment did not show any advantage in terms of glycaemic control or safety in our patients.

Original languageEnglish
Pages (from-to)1186-1192
Number of pages7
JournalDiabetes, Obesity and Metabolism
Volume20
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

Funding

FundersFunder number
Gali Shani-Maimon
Jeevan Scientific Technology Limited
Sanofi

    Keywords

    • basal insulin
    • clinical trial
    • continuous glucose monitoring (CGM)
    • insulin therapy

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