TY - JOUR
T1 - Effect of potassium loading on prostaglandin E2 and F2α excretion in the brattleboro rat
AU - Rathaus, M.
AU - Kariv, N.
AU - Shapira, J.
AU - Podjarny, E.
AU - Bernheim, J.
N1 - Funding Information:
This study was supported by grants from the University (Schrciber Foundation) and the Office Chief Scientist, Ministry of Health, Israel. The authors wish to thank Miss I.Yosef skilled technical assistance.
PY - 1985/9
Y1 - 1985/9
N2 - In order to assess the relative roles played by potassium (K) and the antidiuretic hormone (ADH) on the renal production of prostaglandins (PG) E2 and F2α,the 24 hour urinary excretion of these substances was measured in Brattleboro rats (devoid of ADH) and in control Long Evans heterozygote rats. Rats of each strain received either a normal K intake or a K load for 8 days. Urinary PGE2 and PGF2α were measured by radioimmunoassay in three consecutive 24 h urine collections obtained after the above periods. K loading induced an increase in PGF2α (p<0.01),PGE2 showing a non significant trend to decrease. The E/F ratio was decreased in K loaded animals. The changes were qualitatively similar in presence or absence of ADH, but animals with diabetes insipidus had lower levels of PGs than control animals. The results suggest the possibility that K loading induces an increase in the activity of the renal enzyme PGE2α-9-ketoreductase. The resulting increase in PGF2α could play a role in K excretion and this response is probably independent of ADH.
AB - In order to assess the relative roles played by potassium (K) and the antidiuretic hormone (ADH) on the renal production of prostaglandins (PG) E2 and F2α,the 24 hour urinary excretion of these substances was measured in Brattleboro rats (devoid of ADH) and in control Long Evans heterozygote rats. Rats of each strain received either a normal K intake or a K load for 8 days. Urinary PGE2 and PGF2α were measured by radioimmunoassay in three consecutive 24 h urine collections obtained after the above periods. K loading induced an increase in PGF2α (p<0.01),PGE2 showing a non significant trend to decrease. The E/F ratio was decreased in K loaded animals. The changes were qualitatively similar in presence or absence of ADH, but animals with diabetes insipidus had lower levels of PGs than control animals. The results suggest the possibility that K loading induces an increase in the activity of the renal enzyme PGE2α-9-ketoreductase. The resulting increase in PGF2α could play a role in K excretion and this response is probably independent of ADH.
UR - http://www.scopus.com/inward/record.url?scp=0022355695&partnerID=8YFLogxK
U2 - 10.1016/0262-1746(85)90136-2
DO - 10.1016/0262-1746(85)90136-2
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AN - SCOPUS:0022355695
SN - 0262-1746
VL - 19
SP - 235
EP - 240
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 3
ER -
