Effect of plaque debulking and stenting on short- and long-term outcomes after revascularization of chronic total occlusions

Luis Gruberg, Roxana Mehran, George Dangas, Mun K. Hong, Gary S. Mintz, Ran Kornowski, Alexandra J. Lansky, Kenneth M. Kent, Augusto D. Pichard, Lowell F. Satler, Gregg W. Stone, Martin B. Leon

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: We evaluated the effect of plaque burden modification (debulking) on the short- and long-term clinical outcomes of patients with a totally occluded native coronary artery undergoing successful stent deployment. BACKGROUND: Although the primary success rate of crossing a chronic totally occluded coronary artery has improved with the development of new interventional devices and guidewires, the rate of acute reocclusion and restenosis remains high. METHODS: The in-hospital and late clinical outcomes of 150 patients who had undergone successful stenting of 176 chronic total occlusions were analyzed. After successful crossing of the lesion, 44 patients with 50 lesions underwent debulking by laser angioplasty, rotational or directional atherectomy followed by stenting, whereas 106 patients with 126 lesions underwent stent implantation without prior debulking. RESULTS: Baseline clinical and angiographic characteristics were similar for the two groups, except for a higher incidence of left anterior descending coronary artery location and longer lesions in the group of patients who underwent debulking prior to stenting. In-hospital mortality, myocardial infarction and repeat angioplasty rates were similar for the two groups. At a mean 14 ± 8 months follow-up time, there were no deaths in either group, and target lesion revascularization rates were the same (16.3% in the debulking plus stent group vs. 14.4% in the stent alone group, p = NS). CONCLUSIONS: Treatment of chronic total native coronary artery occlusions with stent deployment with and without lesion modification (debulking) results in a favorable in-hospital outcome, with relatively low long-term target lesion revascularization rates.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalJournal of the American College of Cardiology
Issue number1
StatePublished - Jan 2000
Externally publishedYes


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