Effect of pilocarpine on intraocular pressure in ocular hypertensive subjects

N. Naveh-Floman, V. Stahl, A. D. Korczyn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


In normal subjects, ocular administration of pilocarpine results in initial elevation of IOP succeeded by a fall. We have now examined the effect of pilocarpine on IOP in nontreated ocular hypertension. Our results demonstrate that the initial hypertensive phase is absent in these patients and that the subsequent hypotensive phase is more marked than in normotensive eyes. It is suggested that in normal eyes IOP is regulated by two opposing cholinergic effects, and imbalance between the two may lead to ocular hypertension (or hypotension).

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalOphthalmic Research
Issue number1
StatePublished - 1986


  • Glaucoma
  • Intraocular pressure
  • Ocular hypertension
  • Ocular pharmacology
  • Pilocarpine


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