Effect of percutaneous nephrolithotripsy on renal function: Assessment with quantitative SPECT of^99mTc-DMSA renal scintigraphy

Purpose: To measure the effect of PCNL on global and regional renal function using quantitative single-photon emission CT (SPECT) measurement of Tc-dimercaptosuccinic acid (DMSA) uptake by the kidneys (QDMSA). Patients and Methods: A series of 47 male and 41 female patients with a mean age of 47 ± 16 years were studied by sequential QDMSA examinations before and 1.5 to 24 months after PCNL. Among the 67 patients (76%) in whom PCNL was performed using upper- or lower-pole access, the function of the affected and non-affected poles of the treated kidney was calculated separately. Results: There was no statistically significant difference in the uptake by the treated kidneys before versus after PCNL (11.9% ± 5% v 11.6% ± 5%; t = 0.9; P = 0.368). The total functional volume of the treated kidney was slightly decreased, from 235 cc ± 62 cc to 224 cc ± 59 cc (t = 2.7; P = 0.011). The percent of the injected isotope dose per cubic centimeter of tissue of the treated kidney was not affected (0.051 ± 0.02 v 0.053 ± 0.02; t = 0.86; P = 0.296). Regional assessment revealed a statistically significant decrease in the functional volume at the PCNL port of entry (91 cc ± 30 cc v 82 cc ± 27 cc; t = 2.64; P = 0.013). Regarding the percent of the injected dose per cubic centimeter of renal tissue, no statistically significant difference was found between the area of the kidney that underwent PCNL and the untreated area of the same kidney (0.049 ± 0.02 v 0.05 ± 0.02; t = 0.693; P = 0.494). The function of the contralateral kidneys remained unchanged (13.4% ± 5.2% v 13.6% ± 4.8%; t = 0.68; P = 0.5). Conclusions: Despite the statistically significant decrease in the functional volume of the surgically treated region, neither total percent uptake nor percent of injected dose were reduced significantly. Further studies with long-term follow-up of treated kidneys are required.