TY - JOUR
T1 - Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells
AU - Bessler, H.
AU - Gilgal, R.
AU - Djaldetti, M.
AU - Zahavi, I.
PY - 1986
Y1 - 1986
N2 - The effect of pentoxifylline (Trental) on the phagocytic capacity, cAMP levels, and superoxide anion production of human peripheral blood monocytes and polymorphonuclears (PMNs) was studied. The drug inhibited the phagocytosis of latex particles by both monocytes and PMNs in a dose-dependent manner. In addition, superoxide anion production during the phagocytic process was also reduced following incubation of the cells with pentoxifylline. It is suggested that this inhibitory effect is due to the increased intracellular levels of cAMP induced by the drug.
AB - The effect of pentoxifylline (Trental) on the phagocytic capacity, cAMP levels, and superoxide anion production of human peripheral blood monocytes and polymorphonuclears (PMNs) was studied. The drug inhibited the phagocytosis of latex particles by both monocytes and PMNs in a dose-dependent manner. In addition, superoxide anion production during the phagocytic process was also reduced following incubation of the cells with pentoxifylline. It is suggested that this inhibitory effect is due to the increased intracellular levels of cAMP induced by the drug.
UR - http://www.scopus.com/inward/record.url?scp=0022967477&partnerID=8YFLogxK
U2 - 10.1002/jlb.40.6.747
DO - 10.1002/jlb.40.6.747
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C2 - 3023514
AN - SCOPUS:0022967477
SN - 0741-5400
VL - 40
SP - 747
EP - 754
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 6
ER -