Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells

H. Bessler, R. Gilgal, M. Djaldetti, I. Zahavi

Research output: Contribution to journalArticlepeer-review

211 Scopus citations

Abstract

The effect of pentoxifylline (Trental) on the phagocytic capacity, cAMP levels, and superoxide anion production of human peripheral blood monocytes and polymorphonuclears (PMNs) was studied. The drug inhibited the phagocytosis of latex particles by both monocytes and PMNs in a dose-dependent manner. In addition, superoxide anion production during the phagocytic process was also reduced following incubation of the cells with pentoxifylline. It is suggested that this inhibitory effect is due to the increased intracellular levels of cAMP induced by the drug.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalJournal of Leukocyte Biology
Volume40
Issue number6
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Dive into the research topics of 'Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells'. Together they form a unique fingerprint.

Cite this