Effect of parathyroid hormone and 1,25-dihydroxyvitamin D3 on RNA and heme synthesis by erythroid precursors

D. Zevin, J. Levi, H. Bessler, M. Djaldetti

Research output: Contribution to journalArticlepeer-review

Abstract

Parathyroid hormone (PTH) was shown to stimulate RNA and heme synthesis in 12- to 13-day embryonic mouse liver erythroid cells, thus expressing an erythropoietin-like effect. Incubation of erythroid precursors with 1,25-dihydroxyvitamin D3 (1,25 (OH)2D3) had no effect on heme synthesis, and only slightly increased the RNA synthesis, thus showing no enhancement effect of 1,25 (OH)2D3 on the PTH stimulating effect on erythropoiesis. The recent data show that even a short period of 15 min incubation with PTH was sufficient to increase RNA synthesis by the erythroid precursors. However, high concentration of PTH was essential for its inhibitory effect and upon removal of the hormone the synthetic capacity of the erythroid precursors has returned to control levels.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalMineral and Electrolyte Metabolism
Volume6
Issue number3
StatePublished - 1981
Externally publishedYes

Fingerprint

Dive into the research topics of 'Effect of parathyroid hormone and 1,25-dihydroxyvitamin D3 on RNA and heme synthesis by erythroid precursors'. Together they form a unique fingerprint.

Cite this