Effect of organic sulfur compounds on the chemical and enzymatic transformations of prostaglandin endoperoxide H2

Amiram Raz; Rina Kenig-Wakshal; Michal Schwartzman

doi:10.1016/0005-2760(77)90190-4

Effect of organic sulfur compounds on the chemical and enzymatic transformations of prostaglandin endoperoxide H₂

Amiram Raz^*, Rina Kenig-Wakshal, Michal Schwartzman

^*Corresponding author for this work

Biochemistry Molecular Biology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The effects of several sulfur organic compounds on the enzymatic and non-enzymatic transformations of prostaglandin endoperoxide H₂ to prostaglandins were studied. Mercaptoethanol, methional α-lipoic acid and dimercaptopropanol increased the chemical (i.e. non-enzymatic) reduction of prostaglandin H₂ to prostaglandin F_2α but except for α-lipoic acid, had no effect on the enzymatic conversion of prostaglandin H₂ to prostaglandin. In contrast, reduced glutathione showed no effect on the chemical conversion of prostaglandin H₂, but exerted a marked and specific stimulation on the enzymatic isomerization of prostaglandin H₂ to prostaglandin E₂. This specific effect of glutathione may serve to regulate the overall intracellular activity of prostaglandin synthetase as well as the particular ratio of prostaglandins produced.

Original language	English
Pages (from-to)	322-329
Number of pages	8
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	488
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(77)90190-4
State	Published - 24 Aug 1977

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title = "Effect of organic sulfur compounds on the chemical and enzymatic transformations of prostaglandin endoperoxide H2",

abstract = "The effects of several sulfur organic compounds on the enzymatic and non-enzymatic transformations of prostaglandin endoperoxide H2 to prostaglandins were studied. Mercaptoethanol, methional α-lipoic acid and dimercaptopropanol increased the chemical (i.e. non-enzymatic) reduction of prostaglandin H2 to prostaglandin F2α but except for α-lipoic acid, had no effect on the enzymatic conversion of prostaglandin H2 to prostaglandin. In contrast, reduced glutathione showed no effect on the chemical conversion of prostaglandin H2, but exerted a marked and specific stimulation on the enzymatic isomerization of prostaglandin H2 to prostaglandin E2. This specific effect of glutathione may serve to regulate the overall intracellular activity of prostaglandin synthetase as well as the particular ratio of prostaglandins produced.",

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AB - The effects of several sulfur organic compounds on the enzymatic and non-enzymatic transformations of prostaglandin endoperoxide H2 to prostaglandins were studied. Mercaptoethanol, methional α-lipoic acid and dimercaptopropanol increased the chemical (i.e. non-enzymatic) reduction of prostaglandin H2 to prostaglandin F2α but except for α-lipoic acid, had no effect on the enzymatic conversion of prostaglandin H2 to prostaglandin. In contrast, reduced glutathione showed no effect on the chemical conversion of prostaglandin H2, but exerted a marked and specific stimulation on the enzymatic isomerization of prostaglandin H2 to prostaglandin E2. This specific effect of glutathione may serve to regulate the overall intracellular activity of prostaglandin synthetase as well as the particular ratio of prostaglandins produced.

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Effect of organic sulfur compounds on the chemical and enzymatic transformations of prostaglandin endoperoxide H₂

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