Effect of organic sulfur compounds on the chemical and enzymatic transformations of prostaglandin endoperoxide H2

Amiram Raz*, Rina Kenig-Wakshal, Michal Schwartzman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of several sulfur organic compounds on the enzymatic and non-enzymatic transformations of prostaglandin endoperoxide H2 to prostaglandins were studied. Mercaptoethanol, methional α-lipoic acid and dimercaptopropanol increased the chemical (i.e. non-enzymatic) reduction of prostaglandin H2 to prostaglandin F but except for α-lipoic acid, had no effect on the enzymatic conversion of prostaglandin H2 to prostaglandin. In contrast, reduced glutathione showed no effect on the chemical conversion of prostaglandin H2, but exerted a marked and specific stimulation on the enzymatic isomerization of prostaglandin H2 to prostaglandin E2. This specific effect of glutathione may serve to regulate the overall intracellular activity of prostaglandin synthetase as well as the particular ratio of prostaglandins produced.

Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume488
Issue number2
DOIs
StatePublished - 24 Aug 1977

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