Effect of nutrition on statural growth

Galia Gat-Yablonski*, Francesco De Luca

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

In children, proper growth and development are often regarded as a surrogate marker for good health. A complex system controls the initiation, rate, and cessation of growth, and thus gives a wonderful example of the interactions between genetics, epigenetics, and environmental factors (especially stress and nutrition). Malnutrition is considered a leading cause of growth attenuation in children. This review summarizes our current knowledge regarding the mechanisms linking nutrition and skeletal growth, including systemic factors, such as insulin, growth hormone, insulin-like growth factor-1, fibroblast growth factor-21, etc., and local mechanisms, including mTOR, miRNAs, and epigenetics. Studying the molecular mechanisms regulating skeletal growth may lead to the establishment of better nutritional and therapeutic regimens for more effective linear growth in children with malnutrition and growth abnormalities.

Original languageEnglish
Pages (from-to)46-62
Number of pages17
JournalHormone Research in Paediatrics
Volume88
Issue number1
DOIs
StatePublished - 1 Aug 2017

Keywords

  • Catch-up growth
  • Growth
  • Growth plate
  • Nutrition

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