Effect of nootropic Solcoseryl® on kainic acid-induced excitotoxic brain injury

Matti Mintz; Barbara Knowlton; Michael S. Myslobodsky

doi:10.1016/0091-3057(93)90085-8

Effect of nootropic Solcoseryl® on kainic acid-induced excitotoxic brain injury

Matti Mintz^*, Barbara Knowlton, Michael S. Myslobodsky

^*Corresponding author for this work

School of Psychological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Solcoseryl® (S) has been shown to provide significant cytoprotection in a variety of models of cerebral hypoxia. In the present study, we quantified the epileptiform effects caused by kainic acid administered into the pontine reticular formation of rats and their response to S pretreatment. Compared to saline, the agent appeared to significantly reduce the mortality of rats in the course of status epilepticus. However, S-pretreated rats manifested an increased incidence of behavioral seizures. This untoward effect is attributed to the fact that S improves the functional potential of injured tissue and retards the period of metabolic exhaustion at a time when neuronal activity should be minimized.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(93)90085-8
State	Published - May 1993

Keywords

Excitotoxic lesion
Kainic acid
Mortality
Pontine reticular formation
Solcoseryl®
Status epilepticus

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10.1016/0091-3057(93)90085-8

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abstract = "Solcoseryl{\textregistered} (S) has been shown to provide significant cytoprotection in a variety of models of cerebral hypoxia. In the present study, we quantified the epileptiform effects caused by kainic acid administered into the pontine reticular formation of rats and their response to S pretreatment. Compared to saline, the agent appeared to significantly reduce the mortality of rats in the course of status epilepticus. However, S-pretreated rats manifested an increased incidence of behavioral seizures. This untoward effect is attributed to the fact that S improves the functional potential of injured tissue and retards the period of metabolic exhaustion at a time when neuronal activity should be minimized.",

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AU - Knowlton, Barbara

AU - Myslobodsky, Michael S.

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AB - Solcoseryl® (S) has been shown to provide significant cytoprotection in a variety of models of cerebral hypoxia. In the present study, we quantified the epileptiform effects caused by kainic acid administered into the pontine reticular formation of rats and their response to S pretreatment. Compared to saline, the agent appeared to significantly reduce the mortality of rats in the course of status epilepticus. However, S-pretreated rats manifested an increased incidence of behavioral seizures. This untoward effect is attributed to the fact that S improves the functional potential of injured tissue and retards the period of metabolic exhaustion at a time when neuronal activity should be minimized.

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KW - Kainic acid

KW - Mortality

KW - Pontine reticular formation

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KW - Status epilepticus

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Effect of nootropic Solcoseryl® on kainic acid-induced excitotoxic brain injury

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Keywords

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