Effect of nootropic Solcoseryl® on kainic acid-induced excitotoxic brain injury

Matti Mintz*, Barbara Knowlton, Michael S. Myslobodsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Solcoseryl® (S) has been shown to provide significant cytoprotection in a variety of models of cerebral hypoxia. In the present study, we quantified the epileptiform effects caused by kainic acid administered into the pontine reticular formation of rats and their response to S pretreatment. Compared to saline, the agent appeared to significantly reduce the mortality of rats in the course of status epilepticus. However, S-pretreated rats manifested an increased incidence of behavioral seizures. This untoward effect is attributed to the fact that S improves the functional potential of injured tissue and retards the period of metabolic exhaustion at a time when neuronal activity should be minimized.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalPharmacology Biochemistry and Behavior
Issue number1
StatePublished - May 1993


  • Excitotoxic lesion
  • Kainic acid
  • Mortality
  • Pontine reticular formation
  • Solcoseryl®
  • Status epilepticus


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