Effect of melatonin on active transport of serotonin into blood platelets

Avi Valevski; Ilan Modal; Zohara Jerushalmy; Leonid Kikinzon; Avraham Weizman

doi:10.1016/0165-1781(95)02642-A

Effect of melatonin on active transport of serotonin into blood platelets

Avi Valevski
, Ilan Modal^*
, Zohara Jerushalmy
, Leonid Kikinzon
, Avraham Weizman

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10^-6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10^-12M to 2 × 10^-9M) and at high nonphysiological concentrations (2 × 10^-8M to 2 × 10^-3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10^-5M with IC₅₀ value of 1.1 × 10^-3M) and had no effect at physiological concentrations.

Original language	English
Pages (from-to)	193-196
Number of pages	4
Journal	Psychiatry Research
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(95)02642-A
State	Published - 28 Jul 1995

Keywords

5-Hydroxytryptamine
Pharmacokinetics

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10.1016/0165-1781(95)02642-A

Cite this

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title = "Effect of melatonin on active transport of serotonin into blood platelets",

abstract = "Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10-6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10-12M to 2 × 10-9M) and at high nonphysiological concentrations (2 × 10-8M to 2 × 10-3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10-5M with IC50 value of 1.1 × 10-3M) and had no effect at physiological concentrations.",

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AU - Valevski, Avi

AU - Modal, Ilan

AU - Jerushalmy, Zohara

AU - Kikinzon, Leonid

AU - Weizman, Avraham

PY - 1995/7/28

Y1 - 1995/7/28

N2 - Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10-6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10-12M to 2 × 10-9M) and at high nonphysiological concentrations (2 × 10-8M to 2 × 10-3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10-5M with IC50 value of 1.1 × 10-3M) and had no effect at physiological concentrations.

AB - Previous research has demonstrated that the circadian rhythm of melatonin negatively correlates with that of the sensitivity of platelet serotonin uptake sites. Moreover, serotonin has been found to be a competitive inhibitor of melatonin binding to platelets. The goal of the present study was to investigate whether melatonin directly affects platelet serotonin transport. Blood samples from 12 healthy subjects were assayed for serotonin transport into platelets. Active transport of serotonin (at a concentration of 10-6 M) into blood platelets was measured in the presence of melatonin at physiological concentrations (10-12M to 2 × 10-9M) and at high nonphysiological concentrations (2 × 10-8M to 2 × 10-3M). Melatonin inhibited serotonin uptake by blood platelets at the high concentrations only (|> 10-5M with IC50 value of 1.1 × 10-3M) and had no effect at physiological concentrations.

KW - 5-Hydroxytryptamine

KW - Pharmacokinetics

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Effect of melatonin on active transport of serotonin into blood platelets

Abstract

Keywords

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