Effect of maternal age on neonatal outcomes in very low birth weight singleton infants: a population-based study

Background: Little is known on the impact of maternal age (MA) on very low birth weight (VLBW) infants’ outcomes. We tested the hypothesis that at both ends of MA there are increased adverse neonatal outcomes in VLBW infants. Methods: We used the Israel National Neonatal Network VLBW (≤1500 g) database. Maternal age was stratified as: <20, 20–24, 25–34 (reference group), 35–39 and ≥40 years. Statistical analyses were univariate and multivariable logistic regression analysis. Results: After adjustment, the infant outcomes of older mothers were similar to those of the reference group for mortality, RDS, severe ROP, NEC and sepsis. Mothers < 20 and 20–24 years old had higher odds of IVH grades 3-4 (OR 1.45, 95% CI 1.09–1.93 and OR 1.26, 95% CI 1.10–1.45, respectively), and BPD (OR 1.55, 95% CI 1.13–2.13 and OR 1.40, 95% CI 1.22–1.62, respectively). There were higher odds for PVL in infants of <20 year-old mothers (OR 1.83, 95% CI 1.26–2.65) and in infants of 35–39 year-old mothers (OR 1.38, 95% CI 1.12–1.69). Poor composite outcomes were significantly higher in the youngest maternal age categories (<20-year-old mothers (OR 1.63, 95% CI 1.28–2.08), and 20–24-year-old (OR 1.28, 95% CI 1.15–1.43). Conclusions: Neonatal outcomes differ in relation to maternal age among very low birth weight newborns, with adverse outcomes more predominant in infants of younger mothers.