Effect of m-Chlorophenylpiperazine on plasma homovanillic acid concentrations in healthy subjects

RenéS S. Kahn; Peter Knott; Steven Gabriel; Kimberly DuMont; Lisa Mastroianni; Michael Davidson

doi:10.1016/0006-3223(92)90068-B

Effect of m-Chlorophenylpiperazine on plasma homovanillic acid concentrations in healthy subjects

RenéS S. Kahn^*, Peter Knott, Steven Gabriel, Kimberly DuMont, Lisa Mastroianni, Michael Davidson

^*Corresponding author for this work

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In view of the abundant anatomical and functional interactions between serotonin and dopamine systems, this study examined the effect of the serotonin agonist, m-chlorophenylpiperazine (mCPP) on plasma concentrations of the dopamine metabolite, homovanillic acid. Plasma prolactin levels, body temperature, and mCPP blood level were also measured. mCPP (0.35 mg/kg) and placebo were administered orally to 10 healthy men in a randomized double-blind design. Variables were measured for 210 min after administration of capsules. mCPP raised prolactin and temperature as compared to placebo, but did not affect plasma homovanillic acid concentrations. Results suggest that mCPP does not alter dopamine function.

Original language	English
Pages (from-to)	1055-1061
Number of pages	7
Journal	Biological Psychiatry
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/0006-3223(92)90068-B
State	Published - 1 Dec 1992
Externally published	Yes

Funding

Funders	Funder number
National Institute of Mental Health	R01MH046957

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abstract = "In view of the abundant anatomical and functional interactions between serotonin and dopamine systems, this study examined the effect of the serotonin agonist, m-chlorophenylpiperazine (mCPP) on plasma concentrations of the dopamine metabolite, homovanillic acid. Plasma prolactin levels, body temperature, and mCPP blood level were also measured. mCPP (0.35 mg/kg) and placebo were administered orally to 10 healthy men in a randomized double-blind design. Variables were measured for 210 min after administration of capsules. mCPP raised prolactin and temperature as compared to placebo, but did not affect plasma homovanillic acid concentrations. Results suggest that mCPP does not alter dopamine function.",

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AU - Kahn, RenéS S.

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AU - DuMont, Kimberly

AU - Mastroianni, Lisa

AU - Davidson, Michael

PY - 1992/12/1

Y1 - 1992/12/1

N2 - In view of the abundant anatomical and functional interactions between serotonin and dopamine systems, this study examined the effect of the serotonin agonist, m-chlorophenylpiperazine (mCPP) on plasma concentrations of the dopamine metabolite, homovanillic acid. Plasma prolactin levels, body temperature, and mCPP blood level were also measured. mCPP (0.35 mg/kg) and placebo were administered orally to 10 healthy men in a randomized double-blind design. Variables were measured for 210 min after administration of capsules. mCPP raised prolactin and temperature as compared to placebo, but did not affect plasma homovanillic acid concentrations. Results suggest that mCPP does not alter dopamine function.

AB - In view of the abundant anatomical and functional interactions between serotonin and dopamine systems, this study examined the effect of the serotonin agonist, m-chlorophenylpiperazine (mCPP) on plasma concentrations of the dopamine metabolite, homovanillic acid. Plasma prolactin levels, body temperature, and mCPP blood level were also measured. mCPP (0.35 mg/kg) and placebo were administered orally to 10 healthy men in a randomized double-blind design. Variables were measured for 210 min after administration of capsules. mCPP raised prolactin and temperature as compared to placebo, but did not affect plasma homovanillic acid concentrations. Results suggest that mCPP does not alter dopamine function.

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Effect of m-Chlorophenylpiperazine on plasma homovanillic acid concentrations in healthy subjects

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