Effect of local antimicrobial agents on excisional palatal wound healing: A clinical and histomorphometric study in rats

Avital Kozlovsky, Zvi Artzi, Avraham Hirshberg, Chen Israeli-Tobias, Liat Reich

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To assess the effect of topically applied antimicrobial agents on palatal excisional wound in rats. Materials and Methods: Excisional wounds, 5 mm in diameter, were made in the centre of the palate of 125 Wistar male rats. In four experimental groups, chlorhexidine digluconate (CHX) 0.12% solution, 1% CHX gel, phenolic compounds solution (Listerine®), amine/stannous fluoride solution (Meridol®) and saline solution as a control group were applied daily for 1 min. The wound area was measured photographically and the epithelialization rate was determined histologically at 3, 7, 14 and 21 days post-surgery. Results: The mean wound area and mean distance between the epithelial margins decreased significantly with time (p<0.001) in experimental and control groups, with the greatest wound area reduction and rate of epithelialization on day 14. A significantly superior rate of wound epithelialization (p=0.03) was presented following use of 1% CHX gel and Listerine® and a comparatively inferior one when the Meridol® solution was applied. Conclusions: Each tested antimicrobial agent when applied on an excisional wound with epithelial and connective tissue deficiency did not have a negative effect on the rate of wound closure. The best results were achieved with 1%CHX gel and Listerine®.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalJournal of Clinical Periodontology
Volume34
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Antimicrobial
  • Chlorhexidine
  • Excisional
  • Healing
  • Wound

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