Effect of Local Administration of Levan on Skin Homograft Rejection in Mice (39500)

The influence of subcutaneous levan administration on the survival time of homografts was compared to that of intra-peritoneal administration of levan. It was found that the inhibitory effects on rejection produced by a high dosage of levan administered intraperitoneally were similar to those produced by a much lower subcutaneous dose. Similar inhibitory effects were observed when levan was injected subcutane-ously close to or far from the graft, and it was concluded that the inhibition was not a result of physical damage to the graft bed or mechanical interference with the rejection process.