Effect of levamisole, thymic humoral factor and indomethacin on E-rosette formation of lymphocytes in Hodgkin's disease

B. Ramot, E. Rosenthal, M. Biniaminov, I. Ben-Bassat

Research output: Contribution to journalArticlepeer-review

Abstract

The percent of E-rosette forming cells in the peripheral blood of 60 patients with Hodgkin's disease was significantly lower than in control subjects: 46.4 ± 12.3 vs. 62.4 ± 12.5. Preincubation of the mononuclear cells with levamisole, thymic humoral factor (THF) or indomethacin restored E-rosette formation to normal levels. When monocytes were removed from the mononuclear cell preparations prior to incubation, levamisole and THF retained their activity, whereas indomethacin was inactive. These results suggest a direct effect of levamisole and THF on lymphocytes in Hodgkin's disease, whereas indomethacin requires the mediation of monocytes, similarly to its reported effects on other cellular immune responses in Hodgkin's disease.

Original languageEnglish
Pages (from-to)232-235
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume17
Issue number4
StatePublished - 1981
Externally publishedYes

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