Effect of levamisole on chemotaxis of granulocytes from uremic patients

D. Modai, J. Weissgarten, R. Zolf, S. Peller, Zhan Averbukh, S. Kaufman, Uri Shaked, Natan Cohen, Ahuva Golik, M. Tieder

Research output: Contribution to journalArticlepeer-review


Uremic granulocyte chemotaxis was assessed in the presence of four different concentrations of levamisole. Chemotactic responsiveness of uremic granulocytes was significantly decreased compared to normal, both in the absence of levamisole and with all levamisole concentrations tested. However, with 10-3 and 10-4 M levamisole concentrations, uremic granulocyte chemotaxis was similar to that of normal granulocytes without levamisole. Defective chemotactic activity of granulocytes may play a role in the increased susceptibility of uremic patients to infections. Pharmacological correction of this defect may improve the patients' ability to cope with infections.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
Issue number3
StatePublished - 1988


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