Effect of late initiation of levodopa treatment in patients with long-standing parkinson's disease

Ruth Djaldetti, Therese A. Treves, Doron Merims, Hava Sroka, Eldad Melamed

Research output: Contribution to journalArticlepeer-review

Abstract

The time of initiation of levodopa therapy in patients with Parkinson's disease (PD) is still debatable, as is the hypothesis of levodopa toxicity in vivo. Some researchers argue that late initiation of treatment will delay the appearance of response fluctuations. In the present study, 11 patients in whom treatment with low doses of levodopa was delayed for a mean of 7.9 ± 3.1 years were followed for a mean of 15.7 ± 3.3 years. Time of onset of response fluctuations and disease severity were compared with those in 17 patients with fluctuating PD who were treated with levodopa from disease onset. There was no significant change in time to onset of response fluctuations and dyskinesias once levodopa treatment was started, and late initiation of levodopa did not affect disease progression. The authors conclude that the decision of when to initiate levodopa treatment should be taken according to the patient's needs.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalClinical Neuropharmacology
Volume26
Issue number1
DOIs
StatePublished - Jan 2003

Keywords

  • Levodopa initiation
  • Parkinson's disease
  • Response fluctuations

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