Abstract
In this study the authors examined the effect of azathioprine on the process of placentation and fetal differentiation in rats. From the authors observations, it can be inferred that the high daily doses of azathioprine (10 mg/dl), begun on the 9th day of gestation, induced severe impairment to placental formation and embryonic development and resulted in the subsequent degeneration of the conceptus. The lower doses of 2 and 4 mg/kg per day are similar to those used in therapeutics without deleterious effects. However, in this study, the 4 mg/kg per day dose also interfered with fetal development, which was manifested mainly in retardation of growth and differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 73-75 |
| Number of pages | 3 |
| Journal | Israel Journal of Medical Sciences |
| Volume | 19 |
| Issue number | 1 |
| State | Published - 1983 |
| Externally published | Yes |