Effect of human colostrum on interleukin-2 production and natural killer cell activity

L. Sirota; R. Straussberg; I. Notti; H. Bessler

doi:10.1136/fn.73.2.f99

Effect of human colostrum on interleukin-2 production and natural killer cell activity

L. Sirota, R. Straussberg, I. Notti, H. Bessler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women. At concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited. A time and dose dependent inhibitory effect of colostrum on NK cytotoxicity was also observed. This inhibition could be reversed by the addition of human recombinant IL-2 (hrIL-2). The stimulation of IL-2 production induced by human colostrum might compensate for its inhibitory effect on NK cell activity. These findings suggest an additional mechanism by which breast feeding may affect the neonatal immune system.

Original language	English
Pages (from-to)	F99-F102
Journal	Archives of Disease in Childhood
Volume	73
Issue number	2 SUPPL.
DOIs	https://doi.org/10.1136/fn.73.2.f99
State	Published - 1995
Externally published	Yes

Keywords

colostrum
interleukin-2
natural killer cells
peripheral blood mononuclear cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/fn.73.2.f99

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abstract = "The effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women. At concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited. A time and dose dependent inhibitory effect of colostrum on NK cytotoxicity was also observed. This inhibition could be reversed by the addition of human recombinant IL-2 (hrIL-2). The stimulation of IL-2 production induced by human colostrum might compensate for its inhibitory effect on NK cell activity. These findings suggest an additional mechanism by which breast feeding may affect the neonatal immune system.",

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AU - Sirota, L.

AU - Straussberg, R.

AU - Notti, I.

AU - Bessler, H.

PY - 1995

Y1 - 1995

N2 - The effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women. At concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited. A time and dose dependent inhibitory effect of colostrum on NK cytotoxicity was also observed. This inhibition could be reversed by the addition of human recombinant IL-2 (hrIL-2). The stimulation of IL-2 production induced by human colostrum might compensate for its inhibitory effect on NK cell activity. These findings suggest an additional mechanism by which breast feeding may affect the neonatal immune system.

AB - The effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women. At concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited. A time and dose dependent inhibitory effect of colostrum on NK cytotoxicity was also observed. This inhibition could be reversed by the addition of human recombinant IL-2 (hrIL-2). The stimulation of IL-2 production induced by human colostrum might compensate for its inhibitory effect on NK cell activity. These findings suggest an additional mechanism by which breast feeding may affect the neonatal immune system.

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KW - peripheral blood mononuclear cells

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Effect of human colostrum on interleukin-2 production and natural killer cell activity

Abstract

Keywords

UN SDGs

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