Effect of High-Fat and Low-Fiber Meals on the Cell Proliferation Activity of Colorectal Mucosa

Roger Gregoire, Jona Stadler, Hartley S. Stern, Hanoch Kashtan, Ka Sing Yeung, Garry Neil, W. Robert Bruce

Research output: Contribution to journalArticlepeer-review

Abstract

Normal healthy volunteers (n = 43) were divided into four groups that received diets providing low or high levels of dietary fat (33 or 96 g/day) and low or high levels of dietary fiber (6 and 41 g/day) for a period of five days. Proliferation was assessed with tritiated thymidine labeling of three rectal biopsies. After five days on the prescribed diets, the average thymidine labeling index (LI) of the group on the high fat-low fiber diet was only 25 % higher than the average LI of the group on the low fat-high fiber diet, a difference that is not statistically significant. We conclude that a short-term increase in dietary fat and decrease in dietary fiber does not result in a large increase in cell proliferation rate. (Nutr Cancer 15, 21–26, 1991).

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalNutrition and Cancer
Volume15
Issue number1
DOIs
StatePublished - 1 Jan 1991
Externally publishedYes

Funding

FundersFunder number
McLaughlin Foundation
Ministry of Health of Ontario
Susie Langley
Ludwig Institute for Cancer Research

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