Effect of high doses of 2-CdA on Schwann cells of mouse peripheral nerve

R. Djaldetti, J. Hart, S. Alexandrova, S. Cohen, B. Beilin, M. Djaldetti, H. Bessler

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was undertaken to examine the effect of 2-CdA (Leustatin) on the Schwann cells of myelinated and unmyelinated fibers of peripheral mouse nerve. Two groups of mice were injected intravenously for seven days with 2-CdA: one group received daily doses of 1 mg/kg and the other 0.5 mg/kg. Both doses exceeded those accepted in clinical practice. Mice injected with saline served as controls. The sciatic nerve was then dissected and examined with a transmission electron microscope. The Schwann cells of both the myelinated and unmyelinated nerve fibers of the animals receiving the higher doses of 2-CdA showed nuclear and nucleolus damage, loss of heterochromatin, vacuolization and disorganization of the myelin sheaths. The mesaxons and the axons were also damaged. The Schwann cells of the animals treated with the lower doses appeared undamaged. The results indicate that in contrast to other anticancer drugs known to produce peripheral neuropathy, 2-CdA may cause damage to the Schwann cells only at doses exceeding the therapeutic ones.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Submicroscopic Cytology and Pathology
Volume28
Issue number3
StatePublished - 1996

Keywords

  • 2-CdA
  • Peripheral nerve
  • Schwann cells

Fingerprint

Dive into the research topics of 'Effect of high doses of 2-CdA on Schwann cells of mouse peripheral nerve'. Together they form a unique fingerprint.

Cite this