Effect of high dose and low dose aspirin on survival of random pattern flaps in rats

A. Shalom, M. Westreich

Research output: Contribution to journalArticlepeer-review

Abstract

This paper studies which of the physiological effects of aspirin is responsible for increasing the survival of random flaps in rats, found in an earlier experiment. We wished to confirm that the antiaggregating - antithrombotic effect was responsible for the increased survival of flaps without microvascular anastomosis. Three groups of rats with standardised random pattern flaps were used. The first two were given aspirin 200mg/kg (high dose, n=27) or 40 mg/kg (low dose, n =21) and the third (n=28) acted as controls. The beneficial effects of aspirin were restricted to the high dose group. Since the low dose group also showed antiaggregation of platelets, but without the anti-inflammatory or vasodilatory effects, the results indicate that the antiaggregating effect alone was not responsible for the increased survival of the flaps.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Volume35
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Aspirin
  • Flap
  • Ischemia
  • Prostaglandin I
  • Thromboxane

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