EFFECT OF HAEMORRHAGE ON THE POWER OF LOW FREQUENCY BLOOD PRESSURE FLUCTUATIONS IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS

S. Eliash, O. Oz, S. Akselrod, S. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

1. Before the onset of hypertension low frequency (0.04– 0.1 Hz) MAP fluctuations are reduced in SHR when compared to WKY. We studied the effect of haemorrhage under α1 blockade or angiotensin converting enzyme inhibition (CEI) on the power spectra (PS) of each strain. 2. MAP was recorded from the caudal artery in conscious, 1 month old SHR and WKY. Three groups of rats were studied. Group 1, acute 2 mL haemorrhage; groups 2 and 3, injection of prazosin (0.25–2.5 mg/kg) or captopril (O.5–4 mg/kg), followed by haemorrhage, as in group 1. The PS was divided into 3 frequency bands, 0.004–0.04,0.04–0.07 and 0.07–0.1 Hz. 3. In SHR, although the baseline MAP levels were similar to those of WKY, the PS was significantly damped in each of the 3 frequency bands. 4. Haemorrhage induced a similar MAP fall in both strains accompanied by an increase in the slow MAP fluctuations. However, in SHR the PS response was significantly greater than in WKY. The biggest response was in the slowest (0.004–0.04 Hz) frequency band, 8.7 ± 1.7 vs 1.5 ± 0.4 times baseline levels, respectively. 5. The difference between the two strains in the PS response to haemorrhage was eliminated by α1 blockade. The exaggerated response observed in haemorrhaged, unblocked SHR was reduced in the 3 frequency bands. 6. Captopril reduced the PS response to haemorrhage in SHR to the level observed in WKY in all 3 frequency bands. 7. The enhanced amplification of the MAP fluctuations in haemorrhaged SHR may indicate that SHR requires greater recruitment of control mechanisms than WKY to maintain MAP at a similar level to WKY.

Original languageEnglish
Pages (from-to)S112-Sl13
JournalClinical and Experimental Pharmacology and Physiology
Volume22
DOIs
StatePublished - Nov 1995

Keywords

  • Wistar‐Kyoto rat
  • blood pressure fluctuations
  • captopril
  • haemorrhage
  • hypertension
  • power spectrum
  • prazosin
  • spontaneously hypertensive rat

Fingerprint

Dive into the research topics of 'EFFECT OF HAEMORRHAGE ON THE POWER OF LOW FREQUENCY BLOOD PRESSURE FLUCTUATIONS IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS'. Together they form a unique fingerprint.

Cite this