Abstract
Total peripheral T lymphocytes. OKT4 lielper/incluccr cells and OKT8 suppressor/cytotoxic cells, as well as T lymphocyte function determined by the local xenogeneic graft-versus-host reaction (GVHR). were investigated in 14 psoriatic patients prior to institution of treatment with etretinate, during the course of treatment and ft months after its initiation. After approximately 2 months of treatment, there was a significant increase in the number of E-rosette-forming lymphocytes and OKT4 subpopulations with a return to normal levels after 6 months of treatment. The GVHR was positive in only 5/11 patients prior to therapy but in 9/11 patients after 2 and 6 months. Our results indicate that etretinate has a stimulatory effect on T lymphocytes and their subset counts.
Original language | English |
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Pages (from-to) | 86-89 |
Number of pages | 4 |
Journal | Dermatology |
Volume | 180 |
Issue number | 2 |
DOIs | |
State | Published - 1990 |
Keywords
- Etretinate
- Graft-versus-host reaction
- Psoriasis
- T lymphocyte subpopulations