Effect of etretinate on peripheral T lymphocytes in psoriatic patients before, during and after 6 months of therapy

Michael David, Batya Sholutt, Emmilia Hodak, Miriam Sandbank*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Total peripheral T lymphocytes. OKT4 lielper/incluccr cells and OKT8 suppressor/cytotoxic cells, as well as T lymphocyte function determined by the local xenogeneic graft-versus-host reaction (GVHR). were investigated in 14 psoriatic patients prior to institution of treatment with etretinate, during the course of treatment and ft months after its initiation. After approximately 2 months of treatment, there was a significant increase in the number of E-rosette-forming lymphocytes and OKT4 subpopulations with a return to normal levels after 6 months of treatment. The GVHR was positive in only 5/11 patients prior to therapy but in 9/11 patients after 2 and 6 months. Our results indicate that etretinate has a stimulatory effect on T lymphocytes and their subset counts.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalDermatology
Volume180
Issue number2
DOIs
StatePublished - 1990

Keywords

  • Etretinate
  • Graft-versus-host reaction
  • Psoriasis
  • T lymphocyte subpopulations

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