Effect of estradiol on erythropoiesis and megakaryocytopoiesis in mice

N. Landshman, I. Bleiberg

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of four 1.0-mg estradiol benzoate injections on hemopoiesis in the spleen and bone marrow in mice was studied. The number, concentration and mitotic activity of megakaryocytes (MKC) and number of MKC colonies in the spleen were found to be increased one and two weeks after cessatuon of the estradiol injections. MKC concentration in the bone marrow rose during the experimental period. The MKC increased in number during the first week after estradiol, but dropped to normal after the second week. The number and mitotic activity of erythroid precursors increased in the bone marrow and spleen three days after the cessation of estradiol injections. These findings suggest that estrogen enhanced megakaryocytopoiesis and erythropoiesis in the bone marrow and spleen in mice.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalIsrael Journal of Medical Sciences
Volume15
Issue number2
StatePublished - 1979

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