TY - JOUR
T1 - Effect of diphenyihydantoin on the reproductive function of the male rat
AU - Cohn, Dan F.
AU - Axelrod, T.
AU - Homonna, Z. T.
AU - Paz, G.
AU - Streifler, M.
AU - Kraicer, P. F.
PY - 1978
Y1 - 1978
N2 - Male rats were injected with 5, 10, and 20 mg diphenylhydantoin daily for two months and then caged for five days with cyclic females. Thereafter the males underwent necropsy, the organs of the genital tract were examined, and found to be unaffected. Blood testosterone and Leydig cell counts were normal. A significant reduction of fertility was observed which appears to be loss of libido on behavioural grounds. Except for similar behavioural changes described in human epileptics no further reports are available concerning anticonvulsants and fertility. Our findings indicate that there is no reason to suspect that diphenylhydantoin has endocrine-mediated effects on male fertility in the rat.
AB - Male rats were injected with 5, 10, and 20 mg diphenylhydantoin daily for two months and then caged for five days with cyclic females. Thereafter the males underwent necropsy, the organs of the genital tract were examined, and found to be unaffected. Blood testosterone and Leydig cell counts were normal. A significant reduction of fertility was observed which appears to be loss of libido on behavioural grounds. Except for similar behavioural changes described in human epileptics no further reports are available concerning anticonvulsants and fertility. Our findings indicate that there is no reason to suspect that diphenylhydantoin has endocrine-mediated effects on male fertility in the rat.
UR - http://www.scopus.com/inward/record.url?scp=0017867009&partnerID=8YFLogxK
U2 - 10.1136/jnnp.41.9.858
DO - 10.1136/jnnp.41.9.858
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AN - SCOPUS:0017867009
SN - 0022-3050
VL - 41
SP - 858
EP - 860
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 9
ER -