Effect of dimethyl sulfoxide on cyclic AMP level in chick embryo liver cells

N. Schoenfeld, O. Epstein, L. Nemesh, A. Atsmon

Research output: Contribution to journalArticlepeer-review

Abstract

Dimethyl sulfoxide (DMSO) increased the intracellular levels of cyclic AMP (cAMP) in chick embryo liver cells and in chick embryo liver cell cultures. In chick embryo liver cells maximal cAMP levels were obtained 20 min after injection of DMSO into the eggs. In cultures of the liver cells the effect of DMSO on the cAMP level was immediate. The compounds propylene glycol and glycerol, which, like DMSO, are low-molecular polyhydroxy compounds and have a marked effect on cell membranes, had only a slight effect on cAMP in liver cells in these systems.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalIsrael Journal of Medical Sciences
Volume13
Issue number5
StatePublished - 1977
Externally publishedYes

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