TY - JOUR
T1 - Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin‐1.
AU - Meyer, FA
AU - Yaron, I.
AU - Mashiah, V.
AU - Yaron, M.
PY - 1989/8
Y1 - 1989/8
N2 - Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA). Diclofenac, indomethacin and hydrocortisone inhibited stimulation of PGE production. Half‐maximal inhibition occurred at 1.10 x 10(‐9), 2.79 x 10(‐8) and at 5.52 x 10(‐8) M, respectively. Diclofenac or indomethacin had no effect on HA production, while hydrocortisone had an inhibitory effect (half‐maximal inhibition at 2.76 x 10(‐7) M). This model could be a useful in vitro indicator for the in vivo pharmacological actions of anti‐inflammatory drugs. 1989 The British Pharmacological Society
AB - Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA). Diclofenac, indomethacin and hydrocortisone inhibited stimulation of PGE production. Half‐maximal inhibition occurred at 1.10 x 10(‐9), 2.79 x 10(‐8) and at 5.52 x 10(‐8) M, respectively. Diclofenac or indomethacin had no effect on HA production, while hydrocortisone had an inhibitory effect (half‐maximal inhibition at 2.76 x 10(‐7) M). This model could be a useful in vitro indicator for the in vivo pharmacological actions of anti‐inflammatory drugs. 1989 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0024338220&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1989.tb05416.x
DO - 10.1111/j.1365-2125.1989.tb05416.x
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C2 - 2789072
AN - SCOPUS:0024338220
SN - 0306-5251
VL - 28
SP - 193
EP - 196
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 2
ER -