Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin‐1.

FA Meyer*, I. Yaron, V. Mashiah, M. Yaron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA). Diclofenac, indomethacin and hydrocortisone inhibited stimulation of PGE production. Half‐maximal inhibition occurred at 1.10 x 10(‐9), 2.79 x 10(‐8) and at 5.52 x 10(‐8) M, respectively. Diclofenac or indomethacin had no effect on HA production, while hydrocortisone had an inhibitory effect (half‐maximal inhibition at 2.76 x 10(‐7) M). This model could be a useful in vitro indicator for the in vivo pharmacological actions of anti‐inflammatory drugs. 1989 The British Pharmacological Society

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume28
Issue number2
DOIs
StatePublished - Aug 1989
Externally publishedYes

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