Effect of dead-sea brine and its main salts on cell growth culture

Jashovam Shani, R. Sharon, R. Koren, Z. Even-Paz

Research output: Contribution to journalArticlepeer-review

Abstract

Diluted Dead-Sea brine and solutions of certain of its salts (chlorides and bromides of Na, K and Mg) were found to reversibly inhibit cell proliferation in culture.Bromides were more powerful as inhibitors than their chloride counterparts, and K salts were more effective than those of Na and Mg. KBr had the strongest inhibitory effect, which equalled that of diluted Dead-Sea brine at the same concentration. The favourable results of the Dead-Sea Spa treatment of psoriasis may thus be partly due to the penetration of min erals into the body, via the skin, with subsequent reinforcement of anti-prolifcrativcmechanisms.

Original languageEnglish
Pages (from-to)339-347
Number of pages9
JournalPharmacology
Volume35
Issue number6
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Bromides
  • Cell culture
  • Cell growth
  • Cell proliferation
  • Dead-sea brain
  • Dead-sea salts
  • Psoriasis treatment
  • Thymidine incorporation

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