Effect of controlled exercise training in coronary artery disease patients with and without left ventricular dysfunction assessed by cardiopulmonary indices

Eliezer Klainmanz*, Gershon Fink, Nili Zafrir, Avi Pinchas, Shimon Spitzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiopulmonary indices were used to evaluate the effect of controlled exercise training prescribed on the basis of the heart rate at the ventilatory anaerobic threshold in coronary artery disease patients with and without impaired left ventricular function. Fifty-two patients aged 38-75 years were divided into four groups. The first three groups included patients with a left ventricular ejection fraction of > 45% at rest, as follows: group 1, 10 patients with single-vessel disease; group 2, 12 patients with two-vessel disease; group 3, 10 patients with three-vessel disease. Group 4 comprised 20 patients with left ventricular dysfunction (ejection fraction<35%). The left ventricular ejection fraction was assessed by multigated acquisition radionuclear study. All patients underwent a cardiopulmonary exercise test before and after the program which lasted 6-9 months. The variables measured were oxygen consumption (VO2), CO2 output, minute ventilation, O2 pulse, and ventilatory anaerobic threshold. Significant improvements in maximal VO2, maximal CO2 pulse, and ventilatory anaerobic threshold level were observed in groups 1 2, and 4 (p<0. 1-0.0001), but not in group 3. These findings indicate that the overall cardiac function, as evaluated by cardiopulmonary indices, improves in patients with one- or two-vessel disease with good left ventricular function and in patients with impaired left ventricular function following an exercise training program. Severe coronary disease seems to limit improvement, even in the presence of a good left ventricular function. The results validate the heart rate at the ventilatory anaerobic threshold as the optimal training heart rate in coronary artery disease patients and the cardiopulmonary exercise test as a sensitive tool for evaluating exercise training results.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalCardiology
Volume88
Issue number6
DOIs
StatePublished - 1 Jan 1997

Keywords

  • Cardiac rehabilitation
  • Cardiopulmonary indices
  • Coronary artery disease
  • Exercise testing
  • Exercise training
  • Left ventricular dysfunction

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