Effect of colon carcinoma cell supernatants on cytokine production and phagocytic capacity

Hertzel Salman; Michael Bergman; Hanna Bessler; Yaacov Wolloch; Igor Punsky; Meir Djaldetti

doi:10.1016/S0304-3835(00)00557-7

Effect of colon carcinoma cell supernatants on cytokine production and phagocytic capacity

Hertzel Salman, Michael Bergman, Hanna Bessler, Yaacov Wolloch, Igor Punsky, Meir Djaldetti^*

^*Corresponding author for this work

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The ability of colon carcinoma cells to produce IL-1β, IL-6 and TNFα, and the effect of tumor cell supernatants (sups) on the capacity of peripheral blood mononuclear cells to produce these three cytokines was examined. In addition, the effect of colon carcinoma cell sups on the engulfing capacity of phagocytic cells was detected. The results showed that IL-1β, IL-6 and TNFα levels were significantly higher in tumor cell sups compared with those of autologous colon mucosal cells obtained from healthy tissue. Tumor cell sups caused a decrease in both phagocytic capacity, and the number of latex particles engulfed by each individual cell. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	197-203
Number of pages	7
Journal	Cancer Letters
Volume	159
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00557-7
State	Published - 31 Oct 2000
Externally published	Yes

Funding

Funders	Funder number
Sackler Medical School
Tel Aviv University

Keywords

Colon carcinoma
Interleukins
Phagocytosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(00)00557-7

Cite this

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title = "Effect of colon carcinoma cell supernatants on cytokine production and phagocytic capacity",

abstract = "The ability of colon carcinoma cells to produce IL-1β, IL-6 and TNFα, and the effect of tumor cell supernatants (sups) on the capacity of peripheral blood mononuclear cells to produce these three cytokines was examined. In addition, the effect of colon carcinoma cell sups on the engulfing capacity of phagocytic cells was detected. The results showed that IL-1β, IL-6 and TNFα levels were significantly higher in tumor cell sups compared with those of autologous colon mucosal cells obtained from healthy tissue. Tumor cell sups caused a decrease in both phagocytic capacity, and the number of latex particles engulfed by each individual cell. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Colon carcinoma, Interleukins, Phagocytosis",

author = "Hertzel Salman and Michael Bergman and Hanna Bessler and Yaacov Wolloch and Igor Punsky and Meir Djaldetti",

note = "Funding Information: This work was supported by a grant from the Hamer fund for medical research at the Sackler Medical School, Tel-Aviv University Ramat Aviv. The authors would like to thank IIBR, Israel, for providing the human colon carcinoma cell line. The generous help provided by Mr Ophir Perlson, Atmor, Bnei Brak, Israel is highly appreciated.",

year = "2000",

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doi = "10.1016/S0304-3835(00)00557-7",

language = "אנגלית",

volume = "159",

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journal = "Cancer Letters",

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TY - JOUR

T1 - Effect of colon carcinoma cell supernatants on cytokine production and phagocytic capacity

AU - Salman, Hertzel

AU - Bergman, Michael

AU - Bessler, Hanna

AU - Wolloch, Yaacov

AU - Punsky, Igor

AU - Djaldetti, Meir

N1 - Funding Information: This work was supported by a grant from the Hamer fund for medical research at the Sackler Medical School, Tel-Aviv University Ramat Aviv. The authors would like to thank IIBR, Israel, for providing the human colon carcinoma cell line. The generous help provided by Mr Ophir Perlson, Atmor, Bnei Brak, Israel is highly appreciated.

PY - 2000/10/31

Y1 - 2000/10/31

N2 - The ability of colon carcinoma cells to produce IL-1β, IL-6 and TNFα, and the effect of tumor cell supernatants (sups) on the capacity of peripheral blood mononuclear cells to produce these three cytokines was examined. In addition, the effect of colon carcinoma cell sups on the engulfing capacity of phagocytic cells was detected. The results showed that IL-1β, IL-6 and TNFα levels were significantly higher in tumor cell sups compared with those of autologous colon mucosal cells obtained from healthy tissue. Tumor cell sups caused a decrease in both phagocytic capacity, and the number of latex particles engulfed by each individual cell. (C) 2000 Elsevier Science Ireland Ltd.

AB - The ability of colon carcinoma cells to produce IL-1β, IL-6 and TNFα, and the effect of tumor cell supernatants (sups) on the capacity of peripheral blood mononuclear cells to produce these three cytokines was examined. In addition, the effect of colon carcinoma cell sups on the engulfing capacity of phagocytic cells was detected. The results showed that IL-1β, IL-6 and TNFα levels were significantly higher in tumor cell sups compared with those of autologous colon mucosal cells obtained from healthy tissue. Tumor cell sups caused a decrease in both phagocytic capacity, and the number of latex particles engulfed by each individual cell. (C) 2000 Elsevier Science Ireland Ltd.

KW - Colon carcinoma

KW - Interleukins

KW - Phagocytosis

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VL - 159

SP - 197

EP - 203

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Effect of colon carcinoma cell supernatants on cytokine production and phagocytic capacity

Abstract

Funding

Keywords

UN SDGs

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