Effect of colchicine in the subcorneal pustular dermatosis type of IgA pemphigus

E. Hodak*, M. Lapidoth, M. David

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: IgA pemphigus of the subcorneal pustular dermatosis (SPD) type is characterized by subcorneal acantholysis and by an abundance of neutrophils, making colchicine a reasonable pharmacologic option for treatment. Objective: We attempted to determine the efficacy of colchicine in the treatment of SPD-type IgA pemphigus. Methods: Two patients with SPD-type IgA pemphigus were treated with colchicine 1.5 mg/day as monotherapy. Results: A sustained clinical response was achieved within 2 to 3 weeks of therapy. Relapses were noted each time colchicine was stopped. Conclusion: Colchicine should be considered in the treatment of SPD-type IgA pemphigus.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume40
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

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