Effect of cimetidine on digoxin disposition in peptic ulcer patients

M. Garty*, G. Perry, H. Shmueli, D. Ilfeld, G. Boner, S. Pitlik, J. Rosenfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cimetidine inhibits the renal tubular secretion of creatinine and digoxin is partly excreted by the same pathway. In order to investigate a possible interaction between the two drugs, a randomized cross-over acute study has been conducted. Six patients with duodenal ulcers were given a single dose of digoxin (Dig) 0.75 mg i.v. with and without oral cimetidine 1200 mg/day. Cimetidine significantly reduced creatinine clearance from 157 to 132 ml/min. There was no significant difference in inulin clearance, 99.2 vs 97.5 ml/min, Dig elimination half life 53.9 vs 56.9 h, apparent volume of distribution 11.3 vs 11.6 l/kg, systemic clearance 2.42 vs 2.35 ml/min/kg, renal clearance 1.48 vs 1.62 ml/min/kg or urinary excretion of digoxin 49.5 vs 51.6% of dose without or with cimetidine. These results suggest that cimetidine does not influence the disposition of digoxin.

Original languageEnglish
Pages (from-to)489-491
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume30
Issue number4
DOIs
StatePublished - Jul 1986
Externally publishedYes

Keywords

  • cimetidine
  • digoxin
  • drug interference
  • pharmacokinetics
  • ulcer patients
  • urinary excretion

Fingerprint

Dive into the research topics of 'Effect of cimetidine on digoxin disposition in peptic ulcer patients'. Together they form a unique fingerprint.

Cite this