Effect of chronic misoprostol ingestion on rat gastric morphology and cell turnover

Alexander Fich, Nadir Arber, Elimelech Okon, Gershom Zajicek, Daniel Rachmilewitz

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of long-term misoprostol - a synthetic prostaglandin E1 analogue - ingestion on rat gastric morphology and cell turnover was studied. Misoprostol in a daily dose of 90 μg/kg or 9,000 μg/kg was intragastrically administered to rats. Control rats were treated with the vehicle only. Following 90 days of treatment, 3H thymidine was injected i. v. and rats were sacrificed 1 h later. Tissue sections were prepared from the stomach body and subjected to autoradiography. Misoprostol treatment significantly reduced body weight gain. High dose misoprostol treatment induced significant increases in gastric wall thickness and in gastric gland length. On the other hand, the labelling index was significantly reduced by treatment with high dose misoprostol. These results indicate that chronic administration of misoprostol in high doses increases gastric wall thickness and decreases gastric cell turnover, suggesting that administration of prostanoids causes an increase in cell survival and a decrease in cell shedding.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalArchives of Toxicology
Volume61
Issue number4
DOIs
StatePublished - Feb 1988
Externally publishedYes

Keywords

  • Gastric cell turnover
  • Misoprostol
  • Prostaglandins

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