Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits

Albert Musafija; Asher Barzilai; Jacob Ramon; Ethan Rubinstein

Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits

Albert Musafija, Asher Barzilai, Jacob Ramon, Ethan Rubinstein^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.

Original language	English
Pages (from-to)	473-474
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	42
Issue number	2
State	Published - Feb 1998

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title = "Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits",

abstract = "The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.",

author = "Albert Musafija and Asher Barzilai and Jacob Ramon and Ethan Rubinstein",

year = "1998",

month = feb,

language = "אנגלית",

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pages = "473--474",

journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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AU - Musafija, Albert

AU - Barzilai, Asher

AU - Ramon, Jacob

AU - Rubinstein, Ethan

PY - 1998/2

Y1 - 1998/2

N2 - The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.

AB - The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.

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M3 - מאמר

AN - SCOPUS:0031918578

VL - 42

SP - 473

EP - 474

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 2

ER -

Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits

Abstract

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