Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits

Albert Musafija, Asher Barzilai, Jacob Ramon, Ethan Rubinstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.

Original languageEnglish
Pages (from-to)473-474
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number2
StatePublished - Feb 1998

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