Effect of bicarbonate feeding on intestinal absorption of calcium and vitamin D metabolism in rats

U. Gafter, S. Edelstein, J. Levi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of bicarbonate (NaHCO3) feeding on intestinal absorption of calcium and phosphorus and vitamin D metabolism was investigated. Gut sac uptake of 45Ca and [32P]phosphate in vitro, as well as the plasma level of vitamin D metabolites, was determined in rats fed with NaHCO3 for 9 days and their pair-fed controls. Duodenal uptake of 45Ca and [32P]phosphate by alkalotic rats was less than duodenal uptake by controls. 1,25(OH)2D plasma level was much higher in alkalotic rats than in their controls, and 25(OH)D slightly higher than in controls. These data suggest that NaHCO3 feeding causes a substantial increase in 1,25(OH)2D plasma level, but interferes with calcium and phosphorus absorption in the duodenum.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalClinical Science
Volume68
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Dive into the research topics of 'Effect of bicarbonate feeding on intestinal absorption of calcium and vitamin D metabolism in rats'. Together they form a unique fingerprint.

Cite this