Effect of an adenosine A1 agonist injected into substantia nigra on kindling of epileptic seizures and convulsion duration

L. J. Herberg, I. C. Rose, M. Mintz

Research output: Contribution to journalArticlepeer-review

Abstract

The substantia nigra pars reticulata (SNr) has been reported to be critically involved in the development and propagation of epileptic seizures, while extracellular adenosine appears to be important for making seizures stop. In the present study, an adenosine A1 receptor agonist [N6-cyclohexyladenosine (CHA); 2.0 nmol/side, or vehicle] was injected bilaterally into the SNr shortly before each of the first five of a series of daily kindling stimuli delivered to the rat amygdala. Injections did not affect the acquisition of kindled afterdischarges or the rate at which seizures developed over subsequent kindling sessions, but convulsions occurring 48-72 h after treatment were significantly shortened. Thus, purinergic mechanisms in the SNr do not appear to be specifically involved in the acquisition of kindled seizures but may contribute to a postictal inhibitory process that shortens the convulsive component.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume44
Issue number1
DOIs
StatePublished - Jan 1993

Keywords

  • Adenosine analogs
  • Convulsions
  • Cyclohexyladenosine
  • Epilepsy
  • Kindling
  • Postictal inhibition Substantia nigra

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