Effect of allogeneic tumor cells, interleukin-2 and interleukin-6, on the growth of subcutaneous syngeneic tumors

Avi Eisenthal, Yehuda Skornick, Ofer Merimsky, Ronit Hirsch, Vera Zakut, Ilan Ron, Samario Chaitchik

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we demonstrate the ability of allogeneic M3 tumor cells to induce an antitumor response against the syngeneic tumor, when injected locally together with syngeneic B16 melanoma cells. The replacement of the allogeneic tumor cells with either syngeneic or allogeneic splenocytes had no effect on the growth of the syngeneic tumor. Systemic administration of both interleukin-2 (IL-2) and IL-6 did not affect the antitumor response induced by allogeneic tumor cells. When mice, previously injected with B16 and M3 cells, were rechallenged subcutaneously with B16 tumor cells at a different anatomical site, an inhibitory effect in some, but not all, experiments was observed. Systemic injections of either IL-2 or IL-6 did not alter the antitumor effects of the allogeneic and syngeneic tumor-cell mixtures. The significance of our results in developing immunotherapy modalities based on active immunization with allogeneic tumor cells and selected cytokines is discussed.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalCancer Immunology, Immunotherapy
Volume37
Issue number4
DOIs
StatePublished - Jul 1993
Externally publishedYes

Keywords

  • Allogeneic tumors
  • Cytokines

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