Effect of a low dose of vincristine on platelet production in mice

E. M. Mandel, H. Bessler, M. Djaldetti

Research output: Contribution to journalArticlepeer-review


The effect of a single low dose (0.1 mg/kg) of vincristine (VCR) on platelet production was investigated in C57Bl mice. A parallel increase of circulating platelets and (75Se)-selenomethionine (Se-Met) uptake was observed. The total megakaryocyte count decreased insignificantly 6 hours after VCR injection, followed by an increase after 18 hours. Plasma taken from mice 24 hours after VCR injection was tested for thrombopoietic activity. The post-VCR plasma caused a significant thrombocytosis, increased Se-Met uptake and increased protein synthesis of the platelets, indicating an active overproduction of platelets. These results suggest that the thrombocytosis induced by a low dose of VCR is mediated by a thrombopoietin-like substance.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalExperimental Hematology
Issue number6
StatePublished - 1977
Externally publishedYes


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