Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

Doron Steinberg*, Mark Feldman, Itzhak Ofek, Ervin I. Weiss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Background: Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria. Objectives: In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus. Results: The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05). Conclusions: Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume54
Issue number1
DOIs
StatePublished - Jul 2004

Keywords

  • Anti-adhesion
  • Fructosyltransferases
  • Glucosyltransferases
  • Mutans streptococci

Fingerprint

Dive into the research topics of 'Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm'. Together they form a unique fingerprint.

Cite this