Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

Doron Steinberg; Mark Feldman; Itzhak Ofek; Ervin I. Weiss

doi:10.1093/jac/dkh254

Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

Doron Steinberg^*, Mark Feldman, Itzhak Ofek, Ervin I. Weiss

^*Corresponding author for this work

Clinical Microbiology and Immunology

Hadassah University Medical Centre

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Background: Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria. Objectives: In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus. Results: The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05). Conclusions: Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.

Original language	English
Pages (from-to)	86-89
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	54
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkh254
State	Published - Jul 2004

Keywords

Anti-adhesion
Fructosyltransferases
Glucosyltransferases
Mutans streptococci

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10.1093/jac/dkh254

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abstract = "Background: Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria. Objectives: In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus. Results: The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05). Conclusions: Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.",

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AU - Ofek, Itzhak

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Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm

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