Echocardiographic findings in patients with spontaneous csf leak

Allen L. Pimienta, David L. Rimoin, Mitchel Pariani, Wouter I. Schievink, Eyal Reinstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The presence of cardiovascular abnormalities in patients with spontaneous cerebrospinal fluid (CSF) leaks are not well-documented in the literature, as cardiovascular evaluation is not generally pursued if a patient does not exhibit additional clinical features suggesting an inherited connective tissue disorder. We aimed to assess this association, enrolling a consecutive group of 50 patients referred for spinal CSF leak consultation. Through echocardiographic evaluation and detailed medical history, we estimate that up to 20% of patients presenting with a spontaneous CSF leak may have some type of cardiovascular abnormality. Further, the increase in prevalence of aortic dilatation in our cohort was statistically significant in comparison to the estimated population prevalence. This supports a clinical basis for echocardiographic screening of these individuals for cardiovascular manifestations that may have otherwise gone unnoticed or evolved into a more severe manifestation.

Original languageEnglish
Pages (from-to)1957-1960
Number of pages4
JournalJournal of Neurology
Issue number1
StatePublished - 2014
Externally publishedYes


  • Aortic dilatation
  • Echocardiographic findings
  • Spontaneous CSF leak
  • Spontaneous intracranial hypotension syndrome


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