Echocardiographic dimensions and function in adults with primary growth hormone resistance (Laron Syndrome)

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Abstract

Patients with primary growth hormone (GH) resistance-Laron Syndrome (LS)-have no GH signal transmission, and thus, no generation of circulating insulin-like growth factor-I (IGF-I), and should serve as a unique model to explore the controversies concerning the long-term effect of GH/IGF-I deficiency on cardiac dimension and function. We assessed 8 patients with LS (4 men, 4 women) with a mean ( ± SD) age of 38 ± 7 years (range 22 to 45), and 8 aged-matched controls (4 men, 4 women) with a mean age of 38 ± 9 years (range 18 to 47) by echocardiography at rest, following exercise, and during dobutamine administration. Left ventricular (LV) septum, posterior wall, and end-diastolic diameter were significantly reduced in untreated patients with LS compared with the control group (p <0.05 for all). Systolic Doppler-derived parameters, including LV stroke volume, stroke index, cardiac output, and cardiac index, were significantly lower (p <0.05 for all) than in the control subjects, whereas LV diastolic Doppler parameters, including mitral valve waves E, A, E/A ratio, and E deceleration time, were similar in both groups. LV ejection fraction at rest as well as the stress-induced increment of the LV ejection fraction were similar in both groups. Our results show that untreated patients with long-term IGF-I deficiency have reduced cardiac dimensions and output but normal LV ejection fraction at rest and LV contractile reserve following stress. Copyright (C) 2000 Excerpta Medica Inc.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalAmerican Journal of Cardiology
Volume85
Issue number2
DOIs
StatePublished - 15 Jan 2000
Externally publishedYes

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