Early signaling of inflammation in patients following traumatic injury with accurately estimated time of injury by profiling C-reactive protein levels

Background: Despite its widespread use, the precise dynamics of CRP response in clinical practice remain poorly defined. We employed a novel quadratic model to explore the time-course analysis of CRP values in trauma patients with known precise time of injury. Methods: Relevant data on all adult patients admitted to our hospital following traumatic incidents between January 1st 2010 to December 31, 2020 were retrospectively collected. Those with a documented time of injury and who underwent CRP evaluation within the first 24 h since injury were studied. Results: Based on the findings from our annual health check-up center, we established a reference upper normal CRP value of 12.99 mg/L. Within the first 7 h after injury, the CRP levels of 8–9% of the 1545 study patients exceeded the reference threshold. The proportion of patients with CRP levels > 12.99 mg/L increased to 18.5% at 8–9 h later and rose sharply to 91.6% at 22–24 h later. Our quadratic model yielded the equation: CRP = 5.122–0.528xTime + 0.139xTime ². It accounted for > 40% of the variance in CRP levels (R² = 42.4%). Conclusions: Clear and prominent CRP elevations following atraumatic event are detected only 9–12 h following the insult. This novel finding has crucial implications for accurate CRP assessment of inflammatory responses to physical injuries.